Equisetin

A tetramic acid with antibiotic and cytotoxic activity, and a potent inhibitor of HIV-1 integrase.

The tetramic acid, equisetin, is produced by a number of species of Fusarium. Interest in equisetin emerged with reports of its inhibitory activity against HIV-1 integrase in vitro that was mechanistically distinct from previously described inhibitors. Equisetin inhibits 3 end-processing and strand transfer, as well as disintegration catalysed by either the full-length enzyme or the truncated integrase core.

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