Resveratrol: Efficacy and Applications

Resveratrol (CAS: 501-36-0) is a polyphenolic compound widely found in plants. It appears as a colorless, needle-shaped crystal, easily soluble in ethanol, methanol, chloroform, and acetone, but poorly soluble in water. Resveratrol is utilized in various applications, including as an antioxidant in cosmetics, an antibacterial agent, a skin whitening agent, a sunscreen, and an anti-aging agent.

 

Resveratrol exhibits numerous pharmacological effects, such as inhibiting platelet aggregation, regulating cholesterol levels, and providing antibacterial and anti-aging benefits. Additionally, it has significant anti-inflammatory and antioxidant properties, which can help treat cardiovascular diseases, osteoporosis, acne, and may offer preventive effects against dementia in the elderly.

 

 

 

Properties of Resveratrol

 

CAS No.: 501-36-0

Molecular formula: C14H12O3

Molecular weight: 228.24

 

 

 

Benefits of Resveratrol

 

Whitening and Spot-Removing Effects

Resveratrol can inhibit the activity of melanocytes and tyrosinase, reducing the formation of melanin and achieving a whitening effect. Additionally, resveratrol possesses antioxidant properties, protecting the skin from ultraviolet damage.

 

Antioxidant and Anti-Free Radical

Resveratrol scavenges and inhibits the generation of free radicals, prevents lipid peroxidation, and regulates the activity of antioxidant enzymes.

Cardiovascular and Cerebrovascular Protection

 

Resveratrol protects against cardiovascular and cerebrovascular diseases by reducing myocardial ischemia-reperfusion injury, inhibiting the formation of atherosclerosis and thrombi, and relaxing blood vessels. It also inhibits platelet aggregation, preventing and treating atherosclerosis and other cardiovascular and cerebrovascular conditions.

 

Immune System Regulation

Resveratrol enhances the phagocytic rate of macrophages, providing antiviral, anti-aging, anti-allergic, and liver-protecting effects.

 

Improving Immunity

Resveratrol effectively boosts the body's immunity, particularly by increasing the phagocytic rate of phagocytes, thus improving disease resistance. It also has antiviral, anti-aging, and liver-protecting properties.

 

 

Daily Whitening Application

 

- Resveratrol is a multifunctional compound known for its excellent skin penetration, anti-aging activity, stimulation of collagen production, potent antioxidant properties, and significant anti-inflammatory effects. These properties work synergistically to support and protect skin health, making resveratrol highly valuable in cosmetics and dermatology.

 

- In the development of whitening skin care products, resveratrol has been proven to effectively reduce melanin production, lighten dark spots, promote skin whitening, and even out skin tone. This makes it a key ingredient in whitening formulations.

 

- In whitening mask essences, resveratrol significantly brightens skin color by directly inhibiting tyrosinase activity and reducing melanin production. Its effectiveness as a whitening agent has been experimentally verified, providing significant skin-whitening improvements.

 

- Resveratrol nanoemulsion technology in skin care cosmetics improves its bioavailability through nanoscale encapsulation. This technology not only effectively removes free radicals and provides antioxidant effects but also further inhibits tyrosinase activity, enhancing the whitening effect of cosmetics.

 

- Resveratrol has shown comparable efficacy to low concentrations of arbutin and ethyl vitamin C in inhibiting melanin synthesis and reducing tyrosinase activity. This further proves its effectiveness and competitiveness in the field of skin whitening.

 

- Resveratrol effectively reduces local skin pigmentation through multiple mechanisms, including inhibiting melanin production, regulating the normal metabolism of keratinocytes, and preventing oxidative damage. This results in efficient skin whitening and provides a scientific basis for addressing skin pigmentation issues.

 

- Resveratrol and its derivatives, such as resveratrol triacetate and resveratrol triethanol, exhibit significant whitening potential by specifically inhibiting tyrosinase activity, a key step in melanin synthesis. This indicates their broad application prospects as new candidates in the field of beauty and skin whitening.

 

 

Functional Food Industry Applications

 

- Resveratrol, widely studied as a food supplement, has demonstrated potential benefits across various disease states, including cancer, neurodegeneration, metabolic syndrome, diabetes, obesity, cardiovascular disease, and immune system disorders. These studies highlight its extensive health-promoting effects.

 

- As a highly effective lipoxygenase inhibitor, resveratrol has shown significant potential as a food additive and pharmacological preparation due to its exceptional antioxidant properties and non-toxic side effects. This provides a scientific basis for its inclusion in daily diets.

 

- Resveratrol, a natural polyphenol compound, can regulate circadian rhythms and may positively affect metabolic disorders. Its applications in food have broad prospects, aiming to promote human health and prevent related diseases.

 

- A comprehensive review of clinical cases and commonly used therapeutic doses in the food industry underscores resveratrol's positive impact on managing cardiovascular disease, cancer, diabetes, and obesity, further emphasizing its health benefits.

 

- Daily intake of resveratrol can improve cardiometabolic health by reducing HOMA-IR, LDL-C, and T-Chol levels. This effect is particularly notable in individuals with metabolic syndrome and obesity.

 

- Resveratrol, a dietary polyphenolic phytoalexin, acts as a peroxynitrite scavenger, suggesting that its daily intake may confer multiple health benefits.

 

- Daily dietary supplementation with resveratrol has been found to prevent the appearance of Alzheimer's disease-related markers, enhance cognitive function, and extend the lifespan of SAMP8 mice by activating the AMPK pathway and increasing SIRT1 levels. This provides a new perspective for preventing cognitive decline.

 

- The antibacterial and antioxidant properties of resveratrol highlight its potential application value in improving food quality and safety.

 

 

Pharmaceutical Industry Applications

 

- Given its antioxidant and anti-inflammatory properties, regulatory effects on cell signaling molecules, and extensive clinical benefits in cardiovascular health, resveratrol is attracting considerable attention as a potential drug candidate.

 

- Resveratrol continues to show potential value for drug development due to its multiple properties, including antioxidant, anti-inflammatory, anti-cancer, cardioprotective, and neuroprotective effects.

 

- The positive effects of resveratrol in reducing intestinal sensitivity and reversing decreased intestinal motility suggest its potential as a daily treatment for irritable bowel syndrome (IBS).

 

- In treating chronic airway inflammation such as asthma, resveratrol demonstrates the effectiveness of targeted therapy by reducing the dose of aerosol inhalation and increasing local lung concentration, offering new ideas for asthma management.

 

- Resveratrol has shown the potential to regulate blood sugar by inhibiting α-glucosidase activity, providing a safe and effective means for postprandial blood sugar management.

 

- Given its strong anti-tumor activity, low toxicity, and few side effects, resveratrol shows great potential in developing drugs for endometrial cancer, offering a new option for clinical treatment.

 

- Daily intake of resveratrol may effectively control diabetes and obesity by improving insulin sensitivity and secretion, benefiting patients with these conditions.

 

- As a selective inhibitor of human P450, resveratrol's cancer prevention value is notable, though the specific daily dosage needs clarification.

 

- Clinical studies have shown that daily oral administration of 50 mg of resveratrol has an adjunctive therapeutic effect on mild to moderate acne vulgaris and is better tolerated than topical treatments.

 

- Resveratrol can be safely used up to 5g daily, showing health benefits for various diseases when used alone or in combination, with encouraging clinical trial results.

 

- A systematic review indicated that daily intake of resveratrol can effectively reduce inflammation and oxidative stress, offering potential therapeutic advantages for mild cognitive impairment and Alzheimer's disease.

 

- Resveratrol helps maintain cognitive function by enhancing microvascular plasticity and reducing brain abnormalities, particularly showing positive effects in neurodegenerative diseases such as Alzheimer's disease and dementia.

 

- In a diabetic rat model, daily administration of resveratrol significantly reduced blood glucose levels, delayed the development of insulin resistance, and effectively controlled weight gain, providing a new strategy for managing hyperglycemia.

 

 

Transmitter Material Applications

 

- The potential application of resveratrol in treating neurological diseases has been explored by innovatively introducing a nanotechnology-based drug delivery system. This strategy efficiently loads poorly soluble resveratrol into nanocarriers to achieve brain-targeted delivery, opening new avenues for neurological disease treatment.

 

- The clinical application value of resveratrol delivery systems in treating various lung diseases is not only theoretically sound but also incorporates innovative strategies. This provides new solutions for lung disease treatment.

 

- In cancer treatment, nanomedicines containing resveratrol have shown broad application prospects by significantly improving solubility, stability, and anti-cancer activity against various malignant tumors. These advancements are expected to become an important part of cancer treatment strategies.

 

- The application of resveratrol and its nanotechnology in enhancing skin bioactive effects reveals comprehensive biological activities such as anti-aging, photoprotection, estrogen-like effects, whitening, anti-acne, wound healing, anti-scarring, antibacterial, and anti-skin cancer properties. These innovative breakthroughs have significant implications for skin health and beauty care.

 

 

Use Cases of Resveratrol

 

XinYaDie® employs resveratrol as its cornerstone ingredient, seamlessly integrating polysorbate-60, panthenol, and other potent skincare essentials to deliver remarkable antioxidant, hydrating, and anti-aging benefits to the skin. It effectively tackles signs of aging, rejuvenating skin's firmness, elasticity, and natural radiance.

 

Shinsegae International's High-Elastic Firming Essence, a harmonious blend of esteemed ingredients like resveratrol and sodium hyaluronate, enriched with the soothing aroma of lavender essential oil, deeply nourishes the skin, enhancing its firmness and elasticity. Perfect for sustained use, it significantly addresses skin laxity, restoring a youthful plumpness and vitality.

 

Baicao Health Technology's children's high-efficiency moisturizing cream is meticulously crafted for children's delicate skin. Its formulation centers around resveratrol and beta-carotene, bolstered by natural extracts from centella asiatica root, egg yolk oil, and phenoxyethanol. With isothermal technology and gentle preservatives, it offers comprehensive hydration and protection, nurturing and fortifying the skin barrier, ensuring baby's skin remains healthy, hydrated, and shielded from dryness and discomfort.

 

Pechoin® introduces its Soothing, Refreshing, and Smooth Cleanser (Amino Acid Type), leveraging a gentle amino acid base. Core components encompass resveratrol and sodium lauroyl lactylate, alongside panthenol and polysorbate-80 for hydration and soothing, and natural nourishers like olive leaf extract and sodium hyaluronate. It deeply cleanses while soothing irritation and reinforcing the skin barrier, leaving skin feeling soft, non-tight, and naturally radiant post-wash.

 

Mary Kay® men's moisturizing lotion is tailored exclusively for the unique needs of male skin. It fuses potent skincare ingredients like resveratrol and oligopeptide-1 with boron nitride for smoother skin, C13-14 isoparaffin and sucrose stearate for an optimal tactile experience, and niacinamide and proline to bolster hydration and repair. The inclusion of denatured ethanol facilitates better penetration, offering men a revitalizing, non-greasy moisturizing sensation that leaves skin looking healthy and radiant.

 

TIMEWISE 5X Multi-Effect Facial Cleanser, released by Mary Kay® , is crafted for normal to dry skin types. It showcases efficacious skincare ingredients like resveratrol and oligopeptide-1, balanced with gentle preservatives such as methylisothiazolinone and phenoxyethanol to ensure safety and efficacy. Its cleansing agents, including glyceryl linoleate and coconut glucoside, gently yet thoroughly purify the skin, eliminating excess oil and impurities. The exclusive addition of malachite extract and CI 15850 (colorant) not only enhances product texture but also elevates the cleansing ritual. After use, skin feels refreshed, non-tight, and emanates a healthy glow.

 

 

Reference :

 

1. Javad Sharifi-Rad, et al. Resveratrol biotechnological applications: Enlightening its antimicrobial and antioxidant properties. Journal of Herbal Medicine (2022)

2. Ludovic Everard Bejenaru, et al. Resveratrol: A Review on the Biological Activity and Applications. Applied Sciences (2024)

3. M. C. Pinto, et al. Resveratrol is a potent inhibitor of the dioxygenase activity of lipoxygenase.. Journal of Agricultural and Food Chemistry（1999）

4. Weronika Spaleniak, et al. Resveratrol as a circadian clock modulator: mechanisms of action and therapeutic applications. Molecular biology reports（2023）

5. Larissa Christine Tuffi, et al. Propriedades do resveratrol em pesquisas clínicas e na indústria alimentícia. Brazilian Journal of Development（2020）

6. M.A. Busolo, et al. Antioxidant polyethylene films based on a resveratrol containing Clay of Interest in Food Packaging Applications. Food Packaging and Shelf Life（2015）

7. Consolato Sergi, et al. Usefulness of resveratrol supplementation in decreasing cardiometabolic risk factors comparing subjects with metabolic syndrome and healthy subjects with or without obesity: meta-analysis using multinational, randomised, controlled trials.. Archives of medical sciences. Atherosclerotic diseases（2020）

8. Joseph H. Holthoff, et al. Resveratrol, a dietary polyphenolic phytoalexin, is a functional scavenger of peroxynitrite. Biomarker Research（2010）

9. David Porquet, et al. Dietary resveratrol prevents Alzheimer’s markers and increases life span in SAMP8. Age（2012）

10. Karla Slowing Barillas, et al. Pharmaceutical formulations comprising resveratrol and use thereof. mag（2000）

11. Robert O Bonow, et al. World Heart Day 2002 - The International Burden Of Cardiovascular Disease: Responding To The Emerging Global Epidemic. Circulation（2002）

12. Divya Arora, et al. Therapeutic applications of resveratrol nanoformulations. Environmental Chemistry Letters（2017）

13. Mustafa Hoca, et al. The role of resveratrol in diabetes and obesity associated with insulin resistance.. Archives of Physiology and Biochemistry（2023）

14. Dominique Vervandier-Fasseur, et al. The Potential Use of Resveratrol for Cancer Prevention. Molecules (Basel, Switzerland)（2019）

15. Young Jin Chun, et al. Resveratrol is a selective human cytochrome P450 1A1 inhibitor.. Biochemical and Biophysical Research Communications（1999）

16. Sujit Ponugoti, et al. Oral resveratrol as an adjuvant therapy in the treatment of mild to moderate acne vulgaris: a prospective observational study. INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH（2023）

17. Daiene Santos Buglio, et al. The Role of Resveratrol in Mild Cognitive Impairment and Alzheimer's Disease: A Systematic Review.. Journal of medicinal food（2022）

18. Beek Eline Marleen Van Der, et al. Use of Resveratrol or Another Hydroxylated Stilbene For Preserving Cognitive Functioning. mag（2012）

19. Jankan Chen, et al. Therapeutic use of resveratrol for hyperglycemia. mag（2006）

20. Yong Chool Boo, et al. Human Skin Lightening Efficacy of Resveratrol and Its Analogs: From in Vitro Studies to Cosmetic Applications. Antioxidants（2019）

21. Samira Eghbali-Feriz, et al. Anti-melanogenesis and anti-tyrosinase properties of Pistacia atlantica subsp. mutica extracts on B16F10 murine melanoma cells.. Research in pharmaceutical sciences（2018）

22. Jung-Im Na, et al. Resveratrol as a Multifunctional Topical Hypopigmenting Agent. International journal of molecular sciences（2019）

23. Bruno Fonseca-Santos, et al. The uses of resveratrol for neurological diseases treatment and insights for nanotechnology based-drug delivery systems. International Journal of Pharmaceutics（2020）

24. Louis C. Martineau, et al. Enhancement of muscle cell glucose uptake by medicinal plant species of Canada's native populations is mediated by a common, Metformin-like mechanism. London journal of medicine（2010）

25. Manjusha Annaji, et al. Resveratrol-loaded nanomedicines for cancer applications. Cancer reports（2021）