Ceramide Series and Application Scenarios

Ceramide is a type of phospholipid and a key component of the intercellular lipids in the skin's stratum corneum, making up 40% to 50% of the lipids in this layer. Its molecular structure includes two long-chain alkyl groups, an amide group, and two hydroxyl groups. These features allow ceramide to form a network structure within the stratum corneum, effectively locking in moisture.

 

 

 

Ceramide is crucial for skin health, playing a significant role in maintaining the skin's barrier function, moisturizing, and repair. As a result, it is increasingly used in skincare products.

 

 

Ceramide Series

 

 

Ceramide NS (Ceramide 2): This type quickly penetrates intercellular spaces, providing deep nourishment, stabilizing, and rebuilding connections between cells. It instantly repairs dry and damaged skin, making it an essential care option for sensitive skin.

Ceramide NP (Ceramide 3): Known for its excellent long-lasting moisturizing power, Ceramide NP replenishes the skin's natural lipid barrier, resisting both internal and external stressors. Specially designed for aging skin, it effectively inhibits melanin production, combats oxidation, fades spots, brightens dull skin tones, and works effectively in the form of ceramide glycoside.

 

Ceramide AS (Ceramide 5): This ceramide accelerates the epidermal renewal cycle and builds an efficient water-locking barrier outside the stratum corneum, preventing moisture evaporation. It is ideal for repairing sensitive and dry skin.

 

Ceramide AP (Ceramide 6): Acting like a natural keratin regulator, Ceramide AP gently and efficiently smooths the stratum corneum, giving the skin an even and translucent look. It is milder than traditional acid ingredients, making it more suitable for thicker stratum corneum, achieving gentle skin rejuvenation.

 

Ceramide EOP (Ceramide 9): This ceramide strengthens the integrity of the sebum membrane and regulates overactive sebaceous glands, achieving an optimal water-to-oil ratio in the skin. It significantly improves the skin's self-defense, making it especially suitable for oily skin and those pursuing balanced, youthful skin.

 

 

Product Series

 

The recommended dosage for leave-on and rinse-off cosmetics is 0.01% to 0.1%.

 

 

Ceramide Benefits

Moisturizing Effect: Ceramide is the main component of lipids in the skin's stratum corneum, helping to repair the skin barrier and making the skin soft and radiant. As we age, ceramide levels decrease, leading to dry and dull skin. Ceramide has a strong water-binding ability, locking in moisture by forming hydrogen bonds with water molecules, thereby maintaining the skin's moist state.

 

Protective Effect: Adequate ceramide levels in the skin help resist external stimuli, such as physical and biological damage. A lack of ceramides causes the skin to lose its natural protective function, making it unable to effectively defend against external damage like sunburn or redness in cold environments.

 

Anti-inflammatory Effects: Ceramide has anti-inflammatory properties, inhibiting the release of inflammatory mediators and reducing skin inflammatory responses. This makes ceramide potentially valuable in treating inflammatory skin conditions such as atopic dermatitis.

 

Anti-aging Effect: Ceramide's anti-aging benefits are primarily due to its moisturizing and barrier repair capabilities. It improves skin dryness, flakiness, and roughness, increases the thickness of the epidermal stratum corneum, enhances the skin's water-holding capacity, reduces wrinkles, boosts skin elasticity, and delays skin aging.

 

Other Potential Effects: Ceramide may also regulate cell growth variation and induce apoptosis. These functions suggest that ceramides may play a broader role in maintaining skin health and physiological balance.

 

 

Cosmetics Industry Applications

Stabilization of Active Ingredients: The introduction of ceramide liquid crystal ingredients effectively stabilizes fat-soluble vitamin C in cosmetics. This significantly enhances anti-aging effects and skin penetration, improves antioxidant stability, and reduces the loss of active ingredients, providing significant benefits to the cosmetics industry.

 

Enhanced Skin Barrier Restoration: Stable formulations with high ceramide content, utilizing multi-layer coating film technology, greatly enhance the skin barrier restoration ability of cosmetic compositions.

 

Low Irritation and Moisturizing Effects: Formulas incorporating ceramides or pseudoceramides, dicarboxylic acids, and their salts offer the dual advantages of low irritation and excellent moisturizing effects, presenting new growth opportunities in the ceramide cosmetics industry.

 

Central Role in Skincare Products: Ceramides are essential for maintaining skin barrier function, deeply moisturizing, and treating skin problems such as eczema and acne, thus greatly improving the overall effectiveness of cosmetic formulas.

 

Hair Care Compositions: The innovative use of ceramides in hair care compositions provides in-depth treatment and protection for hair, enhancing hair health and appearance.

 

Ceramide 6 in Cosmetics: Ceramide 6 reduces moisture loss in the skin and hair, maintaining the skin's soft touch and the hair's bright luster, making it an indispensable ingredient in cosmetics.

 

 

Food Industry Applications

 

Organic Gelling Agent: Ceramide shows great potential as an efficient organic gelling agent. It inhibits oil migration, builds a stable structure for unsaturated oils, and protects nutrients that may be lost due to enzymatic hydrolysis in the intestine.

 

Nutritional Compounds: Ceramides derived from Moro blood oranges protect intestinal health, combat the risk of colon cancer, and improve the skin's ability to absorb nutrients, indicating broad application prospects in the food industry.

 

Dual Nourishing Beverages: Ceramide is used in products like collagen and ceramide dual nourishing beverages. These beverages enhance skin moisture and relieve daily stress, providing comprehensive skin care.

 

Skin Health Promoters: Ceramide production promoters, rich in sphingolipids or their derivatives, actively promote skin health, fight signs of aging, and prevent skin dryness, injecting new vitality into the food industry.

 

Portable Food Compositions: Food compositions incorporating ceramides have led to convenient and uniquely flavored foods, such as dry rice flour cakes and rusks, offering consumers a new way to enjoy the health benefits of ceramides.

 

Improved Taste Experience: The food industry overcomes the bitterness, astringency, and irritating smell of ceramides by integrating instant and sustained-release sweetener technology, greatly improving the product's taste experience.

 

 

Pharmaceutical Industry Applications

 

Anti-Pancreatic Cancer Drugs: Short-chain ceramide has achieved a breakthrough in the development of anti-pancreatic cancer drugs. It significantly enhances the efficacy of paclitaxel and even surpasses gemcitabine in therapeutic effectiveness. This marks a new era in the treatment of pancreatic cancer and opens up broad market prospects.

 

Anti-Tumor Synergistic Effects: Ceramides, when used in combination with powerful drugs such as paclitaxel, docetaxel, and doxorubicin, demonstrate anti-tumor synergistic effects. This is particularly evident in the treatment of breast cancer, ovarian cancer, liver cancer, and melanoma, offering more significant therapeutic benefits to patients.

 

Treatment of Autoimmune Diseases: In the exploration of new drug pathways for autoimmune diseases like multiple sclerosis, ceramide-like metabolites such as FTY720 have been intensively studied. Their unique mechanisms reveal another important development direction for ceramides in the pharmaceutical industry.

 

Overcoming Cancer Drug Resistance: Ceramide plays a key role in addressing cancer cell resistance to doxorubicin by upregulating glucosylceramide synthase. This discovery could reshape the design strategy of anticancer drugs and provide new ideas for overcoming drug resistance.

 

Skin Barrier Defense and Problem Solving: A ceramide synthesis promoter combining niacin and serine not only strengthens the skin barrier's defense but also provides effective solutions for various skin problems. This innovative achievement has broad application prospects in both the pharmaceutical and cosmetic fields.

 

 

Product Cases

Flower Energy® Ceramide Essence blends an array of ceramide components - ceramide NP, NS/NG, AS, EOP, and AP - which synergize to deliver a potent moisturizing punch while also exhibiting antioxidant, anti-aging, and skin rejuvenating properties. Furthermore, this essence incorporates complementary ingredients like hydrogenated lecithin, 1,2-hexanediol, and parahydroxyacetophenone, along with an assortment of hydrating agents such as panthenol and sodium PCA, collectively boostering the skin's natural moisture retention capabilities. The incorporation of sodium hyaluronate significantly elevates the product's calming, anti-aging, and restorative abilities, fostering a hydrated, healthy, and youthful complexion.

 

 

Kafuluo® Ceramide Essence blends a diverse range of ceramide ingredients - NS/NG, AS, EOP, AP, and NP, among others - each boasting unique moisturizing, antioxidant, anti-aging, and repairing properties. These ingredients harmoniously collaborate to fortify a robust skincare barrier. Specifically, NS/NG and AS excel in dual-action hydration and anti-aging, while EOP is renowned for its dual benefits of moisturization and antioxidant protection, also addressing repair. AP and NP further amplify the efficacy of antioxidants and repair, nourishing the skin comprehensively. Additionally, this essence ingeniously incorporates ingredients like butylene glycol, cetyl alcohol ethylhexanoate, and caprylic/capric triglyceride, which synergize to provide deep hydration and holistic skin care, catering to the skin's multifaceted needs.

 

The Beauty Workshop® Ceramide Lotion contains carefully selected ceramide ingredients, especially NP, AP and EOP, which each have their excellent moisturizing, anti-oxidation, anti-aging and repair properties, and together provide comprehensive nourishment and protection for the skin. The product also combines multiple ingredients such as butylene glycol and C12-15 alcohol benzoate to synergistically enhance the effect and create a full range of moisturizing and care experience for facial skin. At the same time, specially added ingredients such as parahydroxyacetophenone, hydrogenated lecithin, carnosine, purslane extract and oligopeptide-1 further enhance the product's antioxidant, soothing and anti-aging capabilities.

 

The Beauty Workshop® Ceramide Lotion encapsulates a selection of ceramide ingredients, notably NP, AP, and EOP, each renowned for their exceptional moisturizing, antioxidant, anti-aging, and reparative qualities. Together, they offer comprehensive nourishment and protection to the skin. Furthermore, the lotion harmoniously blends ingredients like butylene glycol and C12-15 alcohol benzoate, enhancing the overall effect and delivering a holistic moisturizing and facial care experience. Concurrently, the specially incorporated components such as parahydroxyacetophenone, hydrogenated lecithin, carnosine, purslane extract, and oligopeptide-1 further bolster the product's antioxidant, soothing, and anti-aging prowess.

 

The Yangfeitang® Ceramide Essence selects diverse ceramide ingredients naturally occurring in the skin, including NS/NG, AS, AP, and EOP. These ingredients collaborate seamlessly to deliver moisturizing, antioxidant, anti-aging, and reparative effects, efficiently preserving skin hydration, safeguarding against environmental stressors, mitigating aging signs, and fostering self-repair mechanisms. Moreover, this essence integrates glycerin, niacinamide, butylene glycol, and other high-performance skincare components, alongside abundant plant extracts like Centella asiatica, Polygonatum odoratum, and Portulaca oleracea. Blended with natural essences such as hyaluronic acid and geranium, it imparts comprehensive and profound hydration, nourishment, and overall protection to the skin's health.

 

 

References:

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