Hyaluronic Acid: Efficacy and Applications

Hyaluronic acid (HA, CAS: 9004-61-9) is a biomacromolecule naturally occurring in the human body. Known for its exceptional moisturizing and lubricating properties, it finds widespread use in cosmetics, medicine, and food industries. Its unique molecular structure allows it to absorb large amounts of water, making it an efficient moisturizer in skincare products.

Hyaluronic acid

In the cosmetics industry, hyaluronic acid is a widely utilized additive in a range of skincare products, including facial creams, eye creams, serums, and lotions. Its primary functions are to provide long-lasting hydration, enhance skin elasticity, diminish the appearance of wrinkles, and protect the skin from environmental damage.

The food and beverage industry incorporates hyaluronic acid into functional drinks and health supplements to promote skin health and improve joint lubrication.

In the medical field, hyaluronic acid plays a crucial role in treating arthritis and related conditions. Its ability to lubricate joint cavities helps reduce pain and inflammation, making it a valuable therapeutic agent in rheumatology.

Product Specifications:

CAS: 9004-61-9

Molecular formula: C14H22NNaO11

Molecular weight: 403.31

Product properties: White crystalline powder

Shelf life: 2 years

Hyaluronic Acid Benefits

Exceptional Hydration: Hyaluronic acid possesses a remarkable water-retention capacity, able to absorb up to hundreds of times its own weight in water. This property allows it to provide deep, long-lasting moisturization to the skin.

Surface Hydration: By increasing the hyaluronic acid content on the skin's surface, it creates a moisturizing and hydrating effect, resulting in smoother, more supple skin.

Enhanced Skin Elasticity: Oral consumption of hyaluronic acid can boost its synthesis within the body, leading to improved skin elasticity and a reduction in the appearance of wrinkles.

Skin Repair Promotion: Hyaluronic acid creates an optimal environment for skin growth, facilitating the synthesis of collagen and elastic fibers. It also enhances nutrient supply, contributing to overall skin health and appearance.

Anti-inflammatory and Anti-aging Properties: By inhibiting the production of certain cellular enzymes and reducing free radical formation, hyaluronic acid exhibits both anti-inflammatory and anti-aging effects.

Cellular Regeneration: Hyaluronic acid provides an ideal medium for cell proliferation and differentiation, directly promoting cell growth, differentiation, reconstruction, and repair processes.

In addition, hyaluronic acid has different effects at different molecular weights:

High molecular weight HA, exceeding 2000 kDa, forms a breathable membrane on the skin's surface. This membrane effectively locks in moisture and prevents evaporation. However, due to its large molecular size, it has limited penetration and is not absorbed by the skin. This type of HA can absorb water many times its volume, creating a mask-like effect that helps retain moisture within the skin.

Medium molecular weight HA, ranging from 500 to 2000 kDa, creates a breathable film on the skin's surface. This film locks in moisture and provides a skin-tightening effect, offering both hydration and a firming benefit.

Low molecular weight HA, typically between 10 and 500 kDa, can penetrate into the skin's dermis. This allows it to function within the skin, locking in moisture and promoting skin metabolism. It enhances skin hydration, smoothness, and elasticity. Due to its better penetration, low molecular weight HA can provide deeper moisturizing, repair, and anti-aging effects.

Oligomeric HA, with a molecular weight less than 10 kDa, can penetrate deep into the dermis. This type of HA provides comprehensive and sustained moisturizing effects, offering long-lasting hydration. With long-term use, oligomeric HA contributes to anti-aging and wrinkle reduction, making it particularly effective for addressing signs of aging.

Each type of hyaluronic acid offers unique benefits based on its molecular weight, allowing for targeted skincare solutions. This diversity enables the development of specialized products that can address various skin concerns, from surface hydration to deep, long-lasting moisturization and anti-aging effects.

Cosmetics industry applications

- Hyaluronic acid (HA) is widely used in the cosmetics industry for its moisturizing properties, anti-aging benefits, and ability to enhance cell affinity due to its key role in the extracellular matrix.

- Hyaluronic acid is the preferred material for dermal fillers in the cosmetic industry because of its biodegradability, natural presence in connective tissue, long-lasting anti-wrinkle effects, and adjustable degradation rate.

- The biocompatibility and hydrating ability of hyaluronic acid make it effective in cosmetic surgery for increasing skin cell moisture and volume.

- Hyaluronic acid particles modified with hydrophobic groups are utilized in cosmetics to moisturize, plump, and reduce skin blemishes by promoting the filling of the epidermis and dermis.

- With its multifunctional properties of moisturizing, firming, anti-wrinkle, and anti-aging, hyaluronic acid is free from harmful substances and can comprehensively address various skin issues.

- Hyaluronic acid's non-immunogenic and wound-healing properties, along with its water-retaining capacity and compatibility with human ions, contribute to its widespread use in cosmetics.

- Hyaluronic acid's biocompatibility, viscoelasticity, and skin permeability make it a preferred material for topical drug delivery and skin treatments.

- Cosmetic formulations combining hyaluronic acid and colostrum significantly improve the elasticity, texture, color, resistance, moisture, and radiance of aging skin.

- Hyaluronic acid chemically modified with organopolysiloxane enhances its moisturizing effect, improves skin feel, and increases compatibility with the skin, making it more suitable for cosmetic applications.

Food Industry Applications

- Hyaluronic acid oral solution is a natural, eco-friendly health product that effectively improves skin elasticity and hydration while reducing wrinkles by promoting metabolism and absorption in the body.

- Functional foods enriched with hyaluronic acid and chondroitin provide moisturizing and anti-aging benefits along with overall health improvements. These foods contain 0.01-5% hyaluronic acid by weight, with a molecular weight range of 1,000 to 3,000,000.

- The inclusion of hyaluronic acid in food products can help prevent and alleviate allergic conditions such as asthma and dermatitis.

- Hyaluronic acid (HA) enhances the mechanical properties and water retention capacity of gel-type protein foods such as cheese, udon noodles, fish cakes, and panna cotta.

- The addition of hyaluronic acid to health foods such as oral liquids, tablets, or soft capsules can boost metabolism, immunity, and disease resistance without causing toxicity.

- A health functional food containing low molecular weight hyaluronic acid (1,000-100,000 Da) can improve skin issues such as wrinkles, hydration, elasticity, and peeling.

- Novel hyaluronic acid with a molecular weight between 1,000-5,000 can be incorporated into food compositions as an active ingredient, offering potential benefits for oral skin health and hydration.

- Adding hyaluronic acid to beer not only enhances the physiological benefits of beer, such as protecting the stomach and liver, but also helps improve blood vessel and joint function.

Pharmaceutical Industry Applications

- Hyaluronic acid plays a crucial role in drug delivery systems and is widely utilized in carriers such as micelles and hydrogels. It is particularly significant in cancer therapy, tissue engineering, and as an adjuvant for vaccine development.

- Hyaluronic acid and its derivatives show great potential in drug delivery systems, efficiently delivering insoluble drugs, peptides, proteins, genes, and vaccines.

- Cross-linked hyaluronic acid has demonstrated unique potential in pharmaceutical applications by enhancing stability against enzymatic degradation and maintaining non-cytotoxicity in lung cell lines.

- Hyaluronic acid enables advanced biomedical applications in tissue engineering, wound healing, cancer therapy, ophthalmology, and cosmetics through innovative formulations such as coatings, nanoparticles, and hydrogels.

- Hyaluronic acid is widely used in drug delivery systems due to its excellent biocompatibility and is particularly suitable for targeting cancer cells with high CD44 expression.

- The biocompatibility, biodegradability, and non-immunogenicity of hyaluronic acid make it an ideal choice for drug delivery systems, effectively improving the targeting and delivery efficiency of bioactive molecules.

- As a versatile filler material, hyaluronic acid has unique pharmaceutical uses in dermatology, as a viscosupplement for osteoarthritis, and in cancer treatment.

- The use of hyaluronic acid and its salts in pharmaceutical compositions offers a new therapeutic strategy for treating cardiac tissue damage, improving cardiac function, and increasing the survival rate and function of transplanted cardiomyocytes.

- In ophthalmology, hyaluronic acid has a wide range of applications, including intravitreal injections, dry eye treatment, and as a moisturizing ingredient in contact lenses, providing patient comfort and helping to treat dry eye syndrome.

References:

1. Aqeela Yasin, et al. (2022). Advances in Hyaluronic Acid for Biomedical Applications. Frontiers in Bioengineering and Biotechnology

2. L. Al-aroomy, et al. (2022). Biomedical applications and effect of hyaluronic acid as a filler material. International Journal of Health Sciences (IJHS)

3. Yiming Huang, et al. (2022). Application of Cross-Linked and Non-Cross-Linked Hyaluronic Acid Nano-Needles in Cosmetic Surgery. International Journal of Analytical Chemistry

4. P. Saranraj, et al. (2013). Hyaluronic Acid Production and its Applications A Review.International Journal of Pharmaceutical & Biological Archive

5. Marc B. Brown, et al. (2015). Hyaluronic acid: a unique topical vehicle for the localized delivery of drugs to the skin. Journal of The European Academy of Dermatology and Venereology

6. Cuifeng Wang, et al. (2018). Application of Hyaluronic Acid. Chinese journal of medical instrumentation

7. Gobbi R. M., et al. (2018). Cosmetic compositions containing hyaluronic acid and colostrum

8. Zahroh D.A.S., et al. (2023). Hyaluronic Acid Microbial Synthesis and Its Explicit Uses in the Development of Nutraceuticals, Biomedicine, and Vaccine Development.

9. Sun, Y., et al.  (2022). Applications of hyaluronic acid and its derivatives-based nanoparticles in drug delivery. [Book Chapter]

10. Sciabica, S., et al.  (2021). Design, Synthesis, Characterization, and In Vitro Evaluation of a New Cross-Linked Hyaluronic Acid for Pharmaceutical and Cosmetic Applications. Pharmaceutics, 5, Citations. [Open access Journal Article].

11. Yasin, A., et al.  (2022). Advances in Hyaluronic Acid for Biomedical Applications. Frontiers in Bioengineering and Biotechnology, 31, Citations. [Open access Journal Article].

12. Kłodzińska, S. N., et al.  (2012). Hyaluronic acid-based nanosystems for drug delivery applications. [Book Chapter].

13. Al-aroomy, L.., et al.  (2022). Biomedical applications and effect of hyaluronic acid as a filler material. International Journal of Health Sciences (IJHS). [Journal Article].

14. Zhou, Q.., et al.  (2021). Therapeutic uses of hyaluronic acid and salts thereof. [Patent].

15. Chang, W.-H.., et al.  (2021). Applications of Hyaluronic Acid in Ophthalmology and Contact Lenses. Molecules

16. Xuemei Chen, et al. (2011). Hyaluronic Acid Oral Solution and Preparation Method Thereof.

17. Kweon Dong Keon, et al. (2006). Functional Food Comprising Hyaluronic Acid and Chondroitin.

18. Jeoung Doo Il, et al. (2008). A Drug, Food, and Cosmetics Containing Hyaluronic Acid for Curing and Preventing Allergy Disease.

19. Hisashi Yamamoto, et al. (2003). Effect of Hyaluronic Acid on the Mechanical Properties and Water-Holding Capacity of Gel-Type Protein Foods.

20. Zhang Xiaosong, et al. (2002). Application of Hyaluronic Acid in Health-Care Food.

21. Kohei Watabe, et al. (2013). Method for Producing Novel Hyaluronic Acid and/or Salt Thereof, and Method for Producing Food Composition, Oral Skin Ameliorating Agent, or Oral Skin Water Content-Increasing Agent Which Contain the Hyaluronic Acid and/or Salt Thereof.

22. Ling Peixue Guo, et al. (2007). Application of Hyaluronic Acid in Wine and Beer Containing Hyaluronic Acid.