Summary
Ursodeoxycholic acid is white powder, odorless and bitter. Mp: 200-204℃。 Soluble in ethanol and glacial acetic acid, soluble in sodium hydroxide test solution, insoluble in chloroform. UDCA is an isomer of CDCA. Its stone dissolving effect is stronger than that of CDCA. It has no diarrhea and liver toxicity. UDCA can reduce cholesterol absorption, cholesterol synthesis and cholesterol content in bile. In addition, UDCA can also reduce the binding fragment of concanavalin A, which can promote the formation of bile crystals and thus inhibit the formation of stones. The combined use of UDCA and CDCA can enhance the stone dissolving effect of their separate use and reduce the side effects at the same time. The combination of the two is mainly used for the treatment of cholesterol gallstones. When the density of gallstones and bile is equal or the CT value of gallstones is lower than 75 units, the dissolution rate of UDCA is the fastest. This product can increase the number of peripheral platelets in patients with cholelithiasis.
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