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Tipiracil

  • CAS Number 183204-72-0
  • Molecular Formula C9H12Cl2N4O2
  • Molecular Weight 183204-72-0
  • Function: thymidine phosphorylase inhibitor
  • Application: For research use only
  • Negotiable/1 Kg/Bag
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    Summary

      Tipiralacil, also known as TPI, is a thymidine phosphorylase inhibitor (TPI). Tipiracil is one of the active components in TAS-102, which is an anticancer drug candidate currently in clinical trials.

      TAS-102 is an antitumor agent composed of a combination of trifluorothymidine (FTD), a nucleoside that incorporates into DNA and inhibits a variety of genetic functions required for the proliferation of cancer cells, and tipiracil hydrochloride (TPI), an inhibitor of thymidine phosphorylase (which degrades FTD) that maintains an effective blood concentration of FTD. Tipiracil protects trifluridine from being broken down when taken orally.

      Seebio also can supply Tipiracil intermediates as below:

      PRODUCT NAME CAS NO. USAGE
      5-Chloro-6-(chloromethyl)-2,4(1h,3h)-pyrimidinedione 73742-45-7 Tipiracil
      3,4-dihydro-2H-pyrrol-5-amine hydrochloride (1:1) 7544-75-4 Tipiracil
      6-(Chloromethyl)uracil 18592-13-7 Tipiracil

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    Properties

      Name: Tipiracil HCl
      CAS#: 183204-72-0
      Chemical Formula: C9H12Cl2N4O2
      Exact Mass: 278.03373
      Molecular Weight: 279.12318
      Elemental Analysis: C, 38.73; H, 4.33; Cl, 25.40; N, 20.07; O, 11.46
      Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
      Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
      Solubility: Soluble in DMSO, not in water
      Shelf Life: >2 years if stored properly

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